I'd say Game and Wario almost counts as themed, in the sense that Jimmy's back to sports and the characters are doing stuff relavent to their personalities/careers? Not totally analogous I guess... If we do get a main series title for the 3DS, I can't really see how it would keep mechanics gimmicks since the 3DS can't really do much more than the DS. Maybe motion controls, but that's a bit awkward and seems like a rehash of Smooth Moves/Twisted. Actually since the Wii U and 3DS both have all the gimmicks of the last 3, I'd love to see a HD remastering like with Rhythm Heaven! Knowing WarioWare, they could even give it a tongue-in-cheek story where Wario's friends stop wanting to develop and he just reuses the old stuff while they pursue other things. I'd love to see DIY comparability too, but that might be a bit optimistic...