Mario -
Grew up with it like everyone else and have played almost every sub-series. Paper Mario 64 still my favorite, SMB3 is a close second. Mario Odyssey is a good look for the series, I'm optimistic about it going forward.
Donkey Kong - DKC and DKL trilogy is a masterpiece in every single way. DK64 had lots of style but no substance. Everything after that was an insult to Rare. Retro's games are only slightly less watered down than trite like Jungle Beat so I'm really checked out of DK these days.
Legend of Zelda - A little too JapanMagicCreative for my tastes, I only enjoy the more abstract ones like Zelda 1 & II or Link's Awakening. Majora's Mask is really cool but I don't enjoy playing it. Didn't bother with BotW.
Metroid - Played Super Metroid as a kid, found it boring. I've never played anything else of this series but Prime looks interesting.
Yoshi - SMW2 is one of the most creatively ripe games to ever come out of Miyamoto and his team, excellent. Everything after that sucked. Woolly World is still boring as hell and all the DS stuff is such a joke. Yoshi is just kiddie shit nowadays.
Kirby - Cutesy Japanese shit, I don't really care about it. Boring. I like some of the characters and designs but that odd Sakurai-y style just puts me off.
Star Fox - Very indifferent. I've only played 64 but didn't really click with me. Then it just turned to furry fanfic bullshit and I tuned the series out.
Pokemon - Uninspired and unfun. Crappy designs. Probably the most kiddie series under the Nintendo umbrella.
F-Zero - I'd take Stunt Race FX over this any day.
Mother - Masterpiece. Mother 3 has some flaws but 1 & 2 are still phenomenal if you can put up with the dated RPG gameplay.
Ice Climber - Why the hell does everyone and their mum have a seething hatred for this game? Of all the games to hate on why fucking Ice Climber? For an arcade game from the co-op heyday it is completely passable. Fun premise, great dixieland music and...oh yeah shitty controls. Fuck this game, it killed my mom.
Game & Watch - Like most people I've never played a real model, but the Gallery titles on Game Boy were some of my favorites as a kid. A great technical innovation for its day and a good time waster. Glad it got immortalized in Smash.
Fire Emblem - JapanMagicCreative bullshit. Tried playing one on the Wii back in the day and found it extremely unengaging. All the 3DS shit and annoying Smash characters really put me off too so yeah, no thanks.
Kid Icarus - Still my second favorite NES game, underappreciated as fuck. I am a very rare case of a Kid Icarus fan prior to Brawl and I'm ALSO one of the people that hated the new animu design. Uprising is a very good game and I enjoyed it but it'll never be what I wanted out of a Kid Icarus revival. Rip.
Wario - Best platformer series to ever come out of Nintendo. Wario himself is the best thing R&D1 ever created, fite me. WarioWare on the other hand bores and disappoints me.
Metal Gear - Never played. Give zero shits about schute games.
Pikmin - pIkMiN 4 iS aLmOsT dOnE, thank you Mayanmoto, very cool. My favorite Miyamoto series, also underappreciated as fuck. Pikmin 2 is the best GameCube game.
R.O.B. - Haven't played Stack-Up or Gyromite. Little substance to either I imagine but the history behind the accessory is interesting.
Sonic - Never played. Sonic the Edgitudehog is stupid and you should feel stupid for liking it
Animal Crossing - Fun for what it is, even though the first few games are kinda sloppy. City Folk is legit a steaming pile of shit.
Mega Man - Played 3 for five minutes once. Can't really form a valid opinion on it, but the NES games are extremely well produced.
Wii Fit - Actually a fun casualasfucktho series.
Punch-Out - Favorite series of all time. R&D3 master race, bois. Shoutouts to Teleroboxer.
Duck Hunt - Really good arcade shooter with a fun theme. Leave it to Nintendo to take a done-to-death formula and make memorable characters and settings and shit out of it.
Pac-Man - It's just Pac-Man, the fuck you want me to say about Pac-Man?
Xenoblade - Never played, miss me with that JapanMagicCreative overinflated 200-hour-long open-world strategy galaxy brain bullshit
Street Fighter - Never played. Really need to someday.
Final Fantasy - Never played again. Noticing a pattern?
Bayonetta - Basically I don't play edgy JapanMagic 3rd party shit
Splatoon - Probably the most inspired thing to come out of Nintendo in the past decade. I normally hate punkish normie-edge shit but I'll admit I had a blast with Sploon 1, extremely fun and really nice worldbuilding. Give it a chance
@KingDragonWario
Castlevania - The original games have asshole design but I still enjoy it. Simon in Smash is the bee's fockin' knees.
Persona - Flavor of the month shit. Nope.